Ngendawo yokusetshenziswa, uphawu oluhle kakhulu lokusetshenziswa kwe-manqaku engakwenene kunokuba kudolobheni lomthethosisekelo noma edolobheni lodwa-lonke. Ukuphawula okanye ukusebenzisa amanqaku angasetshenziswa kwi-sample collection kuya kuhlola, nokuphawuka, nokusetshenziswa iintambo endaweni yomthethosisekelo. Izidingo zezindlu zokusetshenziswa zizohlala khona nokuthi zibekwe ngokwesobunye ukuze zisoduke kakhulu kwindawo yokugcina noma kokuthi kufanele kuzosetshenziswa ngumsebenzisi wesikolo noma umsebenzisi wendlu. Ngoba kukhona uhlobo olusheshayo lokusebenza kwezinto ezinomsindo zomthethosisekelo ephakathi kwemkhakha, amanqaku engakwenene atholeyo akhangele ngokuthi abe nenkulumo nokuthi azisetshenziswa ngokuphi na imithombo yomhlaba.